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Duane Bradley and his surgically-separated brother Belial return in this frightfully gory follow-up to Frank Henenlotter's original monster movie classic, BASKET CASE. After surviving a fall from a hospital window, the two brothers become a target of the media. Duane's aunt, Granny Ruth (played by world-renowned jazz singer Annie Ross), whisks the duo away to a secluded mansion where other freaks-in-hiding live out their days away from public scrutiny. But when a snooping tabloid reporter finds the location of the mutants, Duane his new family must stand together to keep their freedom a secret, and, in all the chaos, Beliah might actually find true love!